Immunreaksjoner ved MS

Den intracellulære signalveien NFkappaB er spiller en viktig rolle ii den inflammatoriske prosessen som leder til vevsskade.

Kilder:

  • Kuby Immunology; Sixth Edition.Publisher: W. H. Freeman & Company; August 15, 2006
  • Agrawal SM;Yong VW; Immunopathogenesis of multiple sclerosis Int Rev Neurobiol 2007
  • R Selter, B Hemmer. ImmunoTargets and Therapy 2013; Update on immunopathogenesis and immunotherapy in multiple sclerosis
  • Bao-Guo Xiao and Hans Link.Trends Immunology Nov. 1999; Is there a balance between microglia and astrocytes in regulating Th1/Th2-cell responses and neuropathologies?
  • Weiner H 2009.The challenge of multiple sclerosis:How do we cure a chronic heterogenous disease? Ann Neurol 65:239-248
  • Losy Jacek.J Neurol Transm 2013: Is MS an inflammatory or primary degenerative disease?
  • Wootla Bharat et.al. Expert Rev.Clin.Immunol. 2013
  • McColl SR. Chemokines and dendritic cells: a crucial alliance. Immunol Cell Biol 2002; 80: 489–96.
  • Neumann M, Fries H, Scheicher C, Keikavoussi P, Kolb-Maurer A,Brocker E, et al. Differential expression of Rel/NF-kappaB and octamer factors is a hallmark of the generation and maturation of dendritic cells. Blood 2000; 95: 277–85.
  • Tas SW, de Jong EC, Hajji N, May MJ, Ghosh S, Vervoordeldonk MJ,et al. Selective inhibition of NF-kappaB in dendritic cells by the NEMO-binding domain peptide blocks maturation and prevents T cell proliferation and polarization. Eur J Immunol 2005; 35: 1164–74.
  • Acarin L, Gonzalez B, Castellano B (2001) Triflusal posttreatment inhibits glial nuclear factor-kappaB, downregulates the glial response, and is neuroprotective in an excitotoxic injury model in postnatal brain. Stroke 32:2394–2402
  • Brambilla R, Bracchi-Ricard V, Hu WH, Frydel B, Bramwell A,Karmally S, Green EJ, Bethea JR (2005) Inhibition of astroglial nuclear factor kappaB reduces inflammation and improves functional recovery after spinal cord injury. J Exp Med 202:145–156
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